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Objective To prepare isophenylcyclopentylamine hydrochloride capsules and evaluate its quality. Methods The suitable excipients were selected by the drug-excipient compatibility test,and after the formulation and preparation process design and screening,the micromeritic property and hygroscopicity of contents of capsules as well as the basic performance and stability of is-ophenylcyclopentylamine hydrochloride capsules were evaluate. Results The selected formulation was composed of isophenylcyclo-pentylamine hydrochloride 10 mg,anhydrous dibasic calcium phosphate 128.7 mg,mannitol 128.7 mg and aerosil 2.7 mg.The angle of repose of intermediate powders was(30.71±1.09)°,aerated and packed bulk densities were(0.76±0.01)and(0.90±0.02)g/ml re-spectively,Hausner value was 1.19±0.01,Carr′s index was(15.86±1.05)%,indicating good flowability and filling property as well as relatively low humidity.The contents,uniformity of contents and dissolution of capsules fulfilled the requirements.The quality of ca-pusles kept well in the 6-month accelerated and long-term stability test.Conclusion The formulation is simple and reasonable,and the preparation process showed a good reproducibility,which might be suitable for industrialization.
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Objective To understand the correlation between the sleep duration and the dangerous self-injurious behaviors of junior school students in Shanghai.Methods By using systematic sampling methods, 21 junior schools were randomly selected from 17 districts in Shanghai.By using simple random sampling methods, 2 classes were randomly selected from each grade of students from each of the selected junior schools.By using the Survey Questionnaire for Health-related Behaviors of Teenagers in Shanghai(junior school students'edition), questionnaire surveys were performed to investigate the sleep duration and the related dangerous self-injurious behaviors of junior school students.Results A total of 6 414 students (of which male students occupied 49.1% and female students occupied 50.9%) were surveyed and the pass rate of questionnaires was 99.55%.The average age of the students surveyed was 13.28±1.84.21.1% of the students surveyed slept less than 7 hours every day, 69.6% thereof slept 7-8 hours every day and 9.3% thereof slept 9 hours or more every day.In the past 12 months, 47.2% of the students surveyed often felt lonely,71.3% thereof felt unhappy because of study stress or unsatisfactory school records and 9.3% thereof cancelled their daily activities for 2 weeks or more because of feeling sad and desperate.11.7% of the students surveyed conducted self-injurious behaviors, 11.9% thereof contemplated suicide, 6.9% thereof made plans for suicide.The sleep duration of the students surveyed was negatively correlated with the rate of psychological depression related to self-injuries as well as the self-injurious behaviors thereof.Conclusion Lack of sleep is common among junior school students in Shanghai, and sleep insufficiency is correlated with self-injurious psychology and behaviors.which suggests that it is very much necessary to provide junior school students with education that improves sleep.
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Objective To explore the relationship between central obesity and asthma of 7-to 9-year-old pupils, and to make clear the direction of research for the next stage.Methods By cluster sampling, 6 primary schools in Shanghai were randomly selected;the parents of all the Grade One and Grade Two pupils thereof were surveyed, and physical examinations were made for these pupils.Rates were compared using the chi-square test, and the numerous factors for the central obesity and asthma of school-age children were analyzed by using the logistic regression analysis model.Results The obesity rate of these pupils was 9.40%, the rate of central obesity thereof was 16.41%, and the rate of pupils who had suffered asthma was 4.37%.The body mass index (BMI) was used in the univariate analysis to assess the nutritional status of pupils.The difference in terms of the rate of asthma between the obesity group and the non-obesity group had no statistic significance.However, the assessment based on waist circumferences showed that excess waist circumferences were related to asthma.However, multivariate regression analyses showed that masculinity, aging, little weekend sleep, good appetite, having no preference for foods, big appetite and fast eating were the risk factors for central obesity.In the model, a history of asthma was an risk factor for central obesity.Conclusion Central obesity is related to asthma for 7-to 9-year-old pupils.It is necessary to continue the follow-up study for factors influencing obesity, and to probe into the relationship between obesity and asthma, thereby providing more evidences for public health practices.